RK-701 is a highly selective and non-genotoxic inhibitor of G9a (IC50 value of 23-27 nM). It selectively up-regulates HbF, γ-Globin, and BGLT3 expression, while down-regulating H3K9me2 expression. It also inhibits BCL11A and ZBTB7A. This product is intended for research use only.
- Highly selective and non-genotoxic G9a inhibitor
- Up-regulates HbF, γ-globin, and BGLT3 expression
- Down-regulates H3K9me2 expression
- Inhibits BCL11A and ZBTB7A
- Exhibits antiproliferative activity against human MOLT-4 cells (GI50: 21.3 nM)
- Increases proportion of HbF expressing cells
- Demonstrates low toxicity